The body's ability to prevent food poisoning by producing a natural antimicrobial compound increases during the day, when exposure to noxious bacteria is most likely, a new study by UT Southwestern scientists suggests. The findings, published online in Cell, could eventually lead to timed therapies and vaccination regimens designed to maximize this immune response.
This study shows that our immune systems are not turned on all the time, which is an unexpected result. Our findings suggest that there are peak times in which the body is more primed to fight infections."
John F. Brooks II, Ph.D., study leader, postdoctoral fellow in the laboratory of Lora Hooper, Ph.D., study co-leader and professor of immunology and microbiology at UTSW
Researchers have long known that virtually all animals follow circadian cycles that are tied to sunrise and sunset. These cycles allow animals to anticipate and prepare for changes in their environment. Disrupting circadian rhythms can have serious health consequences; for example, chronic sleep disruption is related to increased intestinal infection in humans. However, why this occurs has been unclear.
Brooks, Hooper, and their colleagues suspected that antibacterial immunity might change in the intestines on a circadian cycle. To investigate this idea, the researchers looked for rhythms in the expression of natural antimicrobial agents produced in the gut of mice to fight foodborne illness. The researchers saw that in normal lab mice, one of these antimicrobial molecules – known as regenerating islet-derived protein 3g (REG3G) – was more abundant at night, when these nocturnal animals are active, and less so during the day, when mice sleep. However, in mice raised to have no gut bacteria, REG3G was essentially absent throughout both the day and the night.
Searching for the microbial components driving the rhythmic pattern, the researchers found that mice with cycling amounts of REG3G had large resident populations of segmented filamentous bacteria in their guts – microbes typically present in rodents, nonhuman primates, and humans – that have a unique ability to attach to the intestinal lining and change their hosts' gene activity. Further experiments showed that these bacteria attached to the animals' intestinal lining during feeding, probably to siphon off nutrients. When they attached, REG3G production ramped up in the intestines.
This cycling had significant consequences for the ability of mice to fight off infection. When the researchers infected normal mice with bacteria, the animals had higher bacterial burdens and rates of death if they were exposed at sunset than at sunrise. Mice that can't make antimicrobial proteins, including REG3G, had similarly high rates of bacterial burden and death regardless of when they were infected.
If further research shows this phenomenon also occurs in humans, scientists may eventually be able to capitalize on it by timing the administration of synthetic antibiotics for intestinal infections and oral vaccines or finding new ways to avoid intestinal infections altogether.
"These results make me think twice about waking up in the middle of the night and raiding the refrigerator," Hooper says. "It may be more dangerous to eat bacteria-laden potato salad when your gut defenses are lowest."
Brooks II, J.F., et al. (2021) The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock. Cell. doi.org/10.1016/j.cell.2021.07.001.
https://news.google.com/__i/rss/rd/articles/CBMifGh0dHBzOi8vd3d3Lm5ld3MtbWVkaWNhbC5uZXQvbmV3cy8yMDIxMDcyOC9BbnRpYmFjdGVyaWFsLWltbXVuaXR5LW1heS1jaGFuZ2UtaW4tdGhlLWludGVzdGluZXMtYmFzZWQtb24tY2lyY2FkaWFuLWN5Y2xlLmFzcHjSAYABaHR0cHM6Ly93d3cubmV3cy1tZWRpY2FsLm5ldC9hbXAvbmV3cy8yMDIxMDcyOC9BbnRpYmFjdGVyaWFsLWltbXVuaXR5LW1heS1jaGFuZ2UtaW4tdGhlLWludGVzdGluZXMtYmFzZWQtb24tY2lyY2FkaWFuLWN5Y2xlLmFzcHg?oc=5
2021-07-29 01:00:00Z
CAIiEFKV7JORaO_zt7bM3-3TUXcqMwgEKioIACIQZdRflS9INK7zM5FkBi3R3CoUCAoiEGXUX5UvSDSu8zORZAYt0dww17jIBg
Bagikan Berita Ini
0 Response to "Antibacterial immunity may change in the intestines based on circadian cycle - News-Medical.Net"
Post a Comment