Prof Susan Davis AO – $3.9M
The funding will enable a series of RCTs that will evaluate the effectiveness and safety of testosterone to prevent heart failure, muscle mass loss, bone loss and sexual dysfunction in post-menopausal women and women with early menopause. It’ll also allow a cohort study that will investigate the associations between testosterone and other sex steroids with the evolution of cognitive decline, dementia and structural brain changes in older women.
Prof Jamie Cooper AO – $3.5M
This program of research will include major randomised trials in severe traumatic brain injury (TBI), blood transfusion, and extracorporeal life support (ECMO) for severe respiratory failure; supporting the build of national patient registries in TBI, patient blood transfusion, ECMO, and COVID-19 in intensive care settings; and Prof Cooper’s leadership of the NHMRC Centre for Research Excellence in Intensive Care, and the NHMRC Blood Synergy Program; and mentorship of existing programs within the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC).
A/Prof Joanne Ryan – $2.3M
The group will undertake clinical trials to determine whether commonly used medications for cardiovascular health are also effective in reducing cognitive decline and incident dementia in older individuals. They’ll also develop new dementia risk prediction models for population-wide screening, investigate novel prognostic biomarkers for dementia, and identify mechanistic life-course pathways which lead to dementia, thereby opening up new targets for prevention.
A/Prof Eliza Hawkes – $1.6M
This research will personalize lymphoma treatment through international clinical trials assessing novel therapies, a comprehensive cross-cohort biomarker analysis focusing on genomics leveraging tissue bank and clinical trial samples, and studies to evaluate immunotherapy drug biodistribution using sophisticated new imaging technologies.
A/Prof Dion Stub – $1.5M
This research will leverage A/Prof Stub’s extensive clinical network and access to cardiac registries to evaluate a range of pre-hospital interventions in cardiac emergencies with ongoing, unacceptably high rates of morbidity and mortality, and address knowledge gaps in resuscitative care.
Dr Sarah McGuinness – $665K
People living in and visiting resource-poor settings are at increased risk of exposure to infections spread through food, water, mosquitoes and the environment, and preventive strategies often have limited success in real-world scenarios. This research aims to understand and overcome the barriers that limit the effectiveness and uptake of key preventive strategies (such as improved water supplies and vaccination) in these populations in order to improve health outcomes.
Dr Lidia Engel – $554K
This funding will enable methodological research in health economics that will advance the frameworks supporting quality-adjusted life years (QALYs), a commonly used tool to measure both length and quality of life. Current QALY frameworks lack specificity for older adults in particular, and this research program will evaluate current metrics, and generate new evidence to create fairer, socially accepted resource allocation decisions in old age.
Read about all the Investigator Grant recipients across the University.
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2022-10-12 05:56:28Z
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