Assessment of anti‐SARS‐CoV‐2 antibodies level in convalescents plasma. - Wiley

Background

Despite extensive vaccination, the quantity of patients infected with the SARS-CoV-2 virus and its variants continues to grow worldwide. Treating patients with a severe course of COVID-19 is a difficult challenge. One of the generally accepted and specific therapy methods is the use of plasma rich in anti-SARS-CoV-2 antibodies. On the other hand, assessing the antibodies level depending on the time after infection allows for vaccine-decision.

Methods

the study marked the level of anti-SARS-CoV-2 IgG antibodies in 351 COVID-19 convalescent residents of one geographical region in Poland. The study group included blood donors. The studies were cross-sectional and extended to a questionnaire to determine infection severity. The data was compiled statistically. The study considered epidemiological factors, the time from the end of the infection, and infection severity.

Findings

The fastest increase of the antibodies level was observed up to 59 days after COVID-19, and it was statistically significantly higher among men. Higher levels of antibodies were found among people above the average age in both men and women. It was an increase in the level of antibodies since the onset of the disease in men, while in women, it decreased. The antibodies level was also found to depend on the severity of the course of COVID-19 infection.

Conclusions

The optimal group of plasma donors in the studied geographical region is men and women above 39 y.o. after more severe infection. The titer of antibodies increases with time from the disease.

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2021-11-05 17:55:58Z
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