SARS-CoV-2 rewires host chromatin - Nature.com

The conformation of the mammalian 3D genome is highly regulated and has a key role in various biological processes, such as transcription, DNA replication or repair, cell division or cell differentiation. By high-throughput chromosome conformation capture (Hi-C) and analysis, chromatin architecture is structured into A compartments (transcriptionally active euchromatin) and B compartments (transcriptionally inactive heterochromatin), as well as topological-associating domains (TADs) and chromatin loops. It has been shown that some viruses (such as influenza virus) may affect host chromatin; however, it remains elusive whether SARS-CoV-2 restructures the 3D architecture of host chromatin, and if so, how the virus achieves this or what this means to the host cells. In this new study, Wang, Lee et al. characterized the 3D chromatin organization of human cells after acute infection with SARS-CoV-2 using Hi-C and chromatin immunoprecipitation and sequencing (ChIP-seq) methods, and they found that SARS-CoV-2 restructures host chromatin.

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References

Original article

• Wang, R. et al. SARS-CoV-2 restructures host chromatin architecture. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01344-8 (2023)

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1. Nature Reviews Microbiology http://www.nature.com/nrmicro/

   Andrea Du Toit

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1. Andrea Du Toit
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Correspondence to Andrea Du Toit.

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Du Toit, A. SARS-CoV-2 rewires host chromatin. Nat Rev Microbiol (2023). https://doi.org/10.1038/s41579-023-00891-5

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• Published: 03 April 2023

• DOI: https://doi.org/10.1038/s41579-023-00891-5

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